布里莫尼丁酸0.2%和0.15%眼科溶液对静态和动态瞳孔特征的影响
Jing Yang1, Xiaodi Zhang1, Mei Zhong1
1Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Henan Eye Hospital, Zhengzhou, China.
Frontiers in medicine
|May 31, 2023
概括
0.15%的布里莫尼丁酸眼液在ICL手术后提供了更好的视觉质量和比0.2%更少的瞳孔运动. 这表明0.15%可能更适合在植入后经历夜间光的患者.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
背景情况:
- 高近视患者经常接受可植入的Collamer镜头 (ICL) 手术以纠正视力.
- 术后视觉质量和瞳孔动态对于患者的满意度至关重要.
- 布里莫尼丁酸眼滴是由于其α-2上腺激素激动剂特性而使用的,可能会影响瞳孔大小.
研究的目的:
- 为了比较0.2%和0.15%的布里莫尼丁酸眼药的抗水滴作用和光学质量.
- 评估这些度对学生动态和视觉表现在各种照明条件下对高近视患者在ICL植入后的高近视患者的影响.
主要方法:
- 一项前性研究,涉及80名高近视患者,植入V4c ICL.
- 随机灌注0.2%和0.15%的布里莫尼丁酸眼滴术后2周.
- 测量视觉质量,瞳孔大小,中心,折射,在不同的光条件下对症状的评估,在药物给药前和后.
主要成果:
- 在0.15%和0.2%的布里莫尼丁酸组之间,瞳孔直径或速度没有显著差异.
- 与0.2%的组相比,0.15%的组显示出明显较少的瞳孔中心移动和较低的光学散射灯 (OSI).
- 0.15%的小组在低光下表现出优异的视力敏度 (PVA9%,PVA100%) 和降低高阶偏差 (HOA RMS).
结论:
- 0.15%和0.2%的布里莫尼丁酸眼液都表现出类似的抗水作用.
- 0.15%的布里莫尼丁酸盐提供了更好的视觉质量和最小的瞳孔移动,这使得它可能更适合在ICL植入后经历夜间光的患者.
相关概念视频
01:27Open Angle Glaucoma: Treatment
497
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
497
00:59Direct-Acting Cholinergic Agonists: Pharmacological Actions
1.4K
Direct-acting cholinergic agonists exert their pharmacological actions by mimicking the effects of acetylcholine on postsynaptic muscarinic receptors to generate parasympathetic responses. These agents elicit a range of physiological responses, including cardiovascular effects. For example, activation of muscarinic receptors induces bradycardia, decreased cardiac output, reduced peripheral resistance, and consequent hypotension. In the eye, stimulation of M3 receptors leads to smooth muscle...
1.4K
01:28Angle Closure Glaucoma: Treatment
584
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
584
01:25Glaucoma: Overview
636
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
636
01:11Direct-Acting Cholinergic Agonists: Therapeutic Uses
797
Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...
797