肠-微细胞大脑轴的新兴表观遗传动力学:对精神分裂症中加速大脑衰老的实验和临床影响
Benneth Ben-Azu1,2, Elisabetta C Del Re3,4,5, Jared VanderZwaag1
1Division of Medical Sciences, University of Victoria, Victoria, BC, Canada.
Frontiers in cellular neuroscience
|May 31, 2023
概括
精神分裂症 (SCZ) 与大脑过早衰老和肠道细菌的改变有关. 这篇评论探讨了肠-大脑轴如何受到环境和饮食的影响,影响大脑衰老和SCZ,并建议精神病生物作为潜在的治疗方法.
科学领域:
- 神经科学和精神病学 在
- 微生物学和免疫学
背景情况:
- 精神分裂症 (SCZ) 与大脑过早衰老,大脑储备减少和连接性改变有关.
- 表观遗传时钟变化与SCZ和加速衰老有关.
- 大脑衰老,表观遗传学和SCZ等神经精神疾病之间的机制联系需要进一步阐明.
研究的目的:
- 审查将肠道微生物群动态与大脑功能,衰老和神经退行性疾病联系在一起的证据.
- 探索肠-大脑微质轴在SCZ病变发生和病因学的作用.
- 检查环境因素,饮食和治疗干预措施对SCZ相关大脑衰老的影响.
主要方法:
- 对肠-大脑轴,微质和SCZ的实验和临床证据的系统审查.
- 分析影响微生物群组成的因素,包括出生方式,饮食,压力,污染和感染.
- 对抗精神病药物,便微生物种移植和精神病药物对微质功能和大脑衰老的影响的评估.
主要成果:
- 环境因素调节肠道微生物群,通过迷宫和肠道神经系统影响神经元活动和大脑储备.
- 来自微生物群的分子可以激活微质感官,导致异常的大脑可塑性和功能障碍.
- 肠道功能障碍和相关的微质功能障碍与SCZ病理和加速的大脑衰老有关.
结论:
- 肠-大脑微质轴是SCZ病变发生和加速衰老的关键因素.
- 饮食习惯,压力和环境暴露对这个轴有很大的影响.
- 精神病菌和便微生物群移植显示出潜力,通过调节微质功能和减少衰老过程,作为SCZ的新疗法策略.
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