通过与社区咨询委员会合作,加快阿尔茨海默病研究的多样性
Alex Pena-Garcia1, Ralph Richards2, Mollie Richards2
1Marian University College of Osteopathic Medicine Indianapolis Indiana USA.
Alzheimer's & dementia (New York, N. Y.)
|May 31, 2023
概括
社区咨询委员会 (CAB) 与研究人员合作,促进代表性不足的群体 (URG) 在阿尔茨海默病 (AD) 神经成像研究中的招生. 这种合作显著增加了URG推和参与率,证明了多样化临床试验招聘的成功模式.
科学领域:
- 神经科学和临床研究.
- 公共卫生与社区参与
背景情况:
- 从历史上看,代表性不足的群体 (URG) 很难招募临床试验的参与者,特别是在针对阿尔茨海默病 (AD) 的神经成像研究中.
- 社区咨询委员会 (CAB) 提供了一个潜在的途径,可以弥合研究机构和多样化的社区之间的差距.
研究的目的:
- 概述CAB与印第安纳州阿尔茨海默氏病研究中心 (IADRC) 的研究人员之间成功合作的框架.
- 展示这种伙伴关系如何加快URG在AD神经成像研究中的参与.
主要方法:
- CAB和IADRC的研究人员参与了社区和研究互动,以提高URG研究入学率.
- 社区互动包括与专注于URG的组织建立网络,并共同举办外展活动.
- 研究互动包括CAB成员的直接推和完善招聘策略的战略投入.
主要成果:
- 在2019年10月至2022年12月期间,CAB促进了354个URG研究转介中的267个.
- 34名URG参与者参加了IADRC的研究 (需要MRI/PET扫描),其中30人获得了共识诊断.
- 大多数被录取的参与者在认知上正常 (64.7%),轻度认知障碍或早期AD占其余部分.
结论:
- IADRC CAB与研究人员之间的合作伙伴关系显著改善了ADD神经成像研究中非裔美国人/黑人成年人的入学率.
- 这种概念模型显示了增加URG在AD研究中的代表性的希望,并可能适用于其他网站和URG.
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