血homocysteine (Hcy) 度功能作为SPECT评估的急性缺血性中风后缺血性高的预测生物标志物
Yingqiu Wang1, Renhua Hou1, Yan Liu1
1Department of Nuclear Medicine, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, People's Republic of China.
Pharmacogenomics and personalized medicine
|May 31, 2023
概括
血homocysteine (Hcy) 水平可以预测急性缺血性中风 (AIS) 患者的后缺血性过. 在患者中观察到较低的Hcy度后缺血性过,通过SPECT成像识别.
科学领域:
- 神经学 神经学
- 生物化学 生化学
- 医疗成像医学成像
背景情况:
- 高水平的同类氨酸 (Hcy) 与缺血性中风有关.
- 后缺血性溢血是急性缺血性中风 (AIS) 患者的一个关键并发症.
- 需要预测后缺血性高 perfusion 的生物标志物.
研究的目的:
- 在AIS患者中研究血Hcy作为后缺血性溢血的预测生物标志物.
- 通过单光子发射计算机断层扫描 (SPECT) 来评估Hcy的诊断潜力.
主要方法:
- 112名AIS患者被分为后缺血性高 perfusion (+) 和 (-) 组.
- 收集并比较人口统计,临床病理学和生物化学数据.
- 评估血Hcy和cystatin-C (Cys-C) 水平;进行ROC分析.
主要成果:
- 群体之间的人口或临床病理学数据没有显著差异.
- 低血清Hcy水平被发现在后缺血性高 perfusion (+) 组.
- 经过ROC分析,证实了Hcy水平与后缺血性过之间存在显著的关联.
结论:
- 血Hcy度作为一个验证的预测生物标志物用于AIS患者的SPECT评估后缺血性过.
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