抗抑郁药和SARS-CoV-2 Omicron感染的严重程度之间的关系:使用真实世界的数据进行了一项回顾性队列研究
Huwen Wang1, Yuchen Wei1, Chi Tim Hung1
1School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
The Lancet regional health. Western Pacific
|May 31, 2023
概括
在COVID-19患者中,抗抑郁药的使用与严重结果的风险降低有关,包括ICU入院和死亡. 这表明抗抑郁药可能会对严重的SARS-CoV-2感染提供保护性益处.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 有限的现实世界数据存在于抗抑郁药对SARS-CoV-2 Omicron感染后严重结果的影响.
- 抗抑郁药的使用是常见的,需要对其在病毒感染期间的作用进行调查.
研究的目的:
- 评估抗抑郁药使用与严重的COVID-19结果之间的关联.
- 分析抗抑郁药对重症监护室入院和住院患者死亡率的影响.
主要方法:
- 使用倾向-得分匹配的回顾性队列研究.
- 在Omicron浪潮期间,对香港成年COVID-19患者的住院和药物记录的分析.
- 考克斯的比例危险模型用于估计严重结果的危险比率.
主要成果:
- 抗抑郁药的使用与显著降低ICU入院率 (aHR=0.332) 和住院患者死亡率 (aHR=0.868) 相关.
- 严重的COVID-19综合结果显示,使用抗抑郁药的风险降低 (aHR=0.786).
- 在选择性血清素再吸收抑制剂 (SSRI) 和非SSRI之间,效果是一致的,而西显示出特别的益处.
结论:
- 抗抑郁药的使用与严重COVID-19结果的风险降低相关.
- 研究结果支持继续治疗COVID-19患者的抗抑郁药.
- 抗抑郁药显示出作为严重COVID-19的治疗选择的潜力.
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