查伊胡·舒甘·桑通过调节易衰老的老鼠的肠道微生物群来改善认知缺陷 8
Zhiyue Li1,2, Qiang Zeng1,2,3, Shengquan Hu1
1The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Frontiers in pharmacology
|May 31, 2023
概括
柴胡舒根桑 (CSS) 通过调节肠道微生物群来改善老年小鼠的认知缺陷. 这种传统的中医药减少神经元损伤和Aβ沉积,为阿尔茨海默病的预防提供了潜在的潜力.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 传统中医药在阿尔茨海默病 (AD) 预防方面表现有前途.
- 草药配方Chaihu Shugan San (CSS) 含有可能改善AD的成分.
- 人们越来越认识到肠-大脑轴在神经退行性疾病中的作用.
研究的目的:
- 为了评估CSS对老化加速性鼠标易受8 (SAMP8) 鼠标认知缺陷的影响.
- 研究CSS对老年小鼠微生物群-肠-大脑轴的影响.
- 探索CSS在预防认知衰退方面的潜在机制.
主要方法:
- SAMP8小鼠接受了低剂量 (CSSL) 和高剂量 (CSSH) 的CSS治疗,持续了8周.
- 用莫里斯水迷宫测试来评估认知功能.
- 分析了神经元损伤,Aβ沉积,突触超结构和肠道微生物群组成 (16S rRNA).
主要成果:
- 在老年SAMP8小鼠中,CSS显著改善了学习和记忆.
- CSS治疗改善了神经元损伤,突触损伤和Aβ沉积在大脑中的情况.
- 在CSS调节的肠道微生物群中,增加了Lactobacillus reuteri,减少了Staphylococcus xylosus.
结论:
- CSS证明了对抗衰老中的认知缺陷的预防潜力.
- 肠道微生物群的调节似乎是CSS有效性的关键机制.
- 在轻度认知障碍和阿尔茨海默病中,CSS可以作为治疗剂.
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