在服用氨酸激酶抑制剂的患者中,比较心律不整的模式
Chen Wei1, Muhammad Fazal2, Alexander Loh3
1Department of Internal Medicine, Stanford University, Stanford, CA, USA.
概括
布鲁顿的氨酸激酶 (BTK) 抑制剂易布鲁丁尼与血液性恶性瘤患者中心房和心室心律不整的发病率较高有关. 这导致治疗中断的频率比其他氨酸激酶抑制剂 (TKI) 更高.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 氨酸激酶抑制剂 (TKIs) 在治疗血液性恶性瘤方面至关重要.
- 有限的数据表明TKIs,特别是ibrutinib (布鲁顿的氨酸激酶抑制剂) 与治疗限制性心律失常之间存在联系.
- 需要对不同TKI疗法的心律失常负担进行全面评估.
研究的目的:
- 为了比较患有血液恶性瘤的患者中心律不整的患病率,接受ibrutinib与非布鲁顿的氨酸激酶 (BTK) TKI和非TKI疗法.
- 评估这些心律失常对治疗延续的影响.
主要方法:
- 对193名在2014年至2022年期间接受治疗的血液性恶性瘤患者的回顾性分析.
- 患者使用长期心脏事件监测器进行监测.
- 对比组包括ibrutinib,非BTK TKI和非TKI疗法.
主要成果:
- 与非BTK TKI (15%,17%) 和非TKI (20%,27%) 组相比,ibrutinib组 (n=72) 的心房 (44%) 和非持续性心房动脉短心 (43%) 的患病率显著更高.
- 与非BTK TKIs (4%) 相比,使用ibrutinib的治疗导致治疗中断率较高 (25%) 由于心律不整.
结论:
- 易布鲁替尼与患有血液性恶性瘤的患者中心房和心室心律不整的负担更大.
- 这些心律失常常常需要治疗中断,突出了易布鲁替尼治疗的关键安全性考虑.
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