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在抗生素适应过程中,在群体细菌中直接观察纳米追踪器运输
Xiaodong Wen1, Yuqian Sang1, Yongyu Zhang1
1Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084, China.
ACS nano
|May 31, 2023
概括
合作的Serratia marcescens细菌通过改变流动模式,增强物质运输和表现出超扩散来适应增加的抗生素剂量. 一小部分长长的细菌驱动这种对环境压力的集体反应.
科学领域:
- 微生物学 微生物学
- 流体动力学 流体动力学
- 生物物理学的生物物理.
背景情况:
- 微生物必须适应环境变化才能生存.
- 塞拉提亚马尔塞森斯细菌表现出合作行为.
研究的目的:
- 研究细菌对逐渐恶化的环境的群体级反应.
- 了解细菌如何修改流体动力学以在抗生素压力下生存.
主要方法:
- 使用了合作的Serratia marcescens细菌.
- 应用越来越多的抗生素剂量.
- 采用单纳米粒子追踪来分析时空运输.
- 观察到活跃的流和流动模式的转变.
主要成果:
- 细菌将同质的流转化为大规模的带有缺陷和的阴性喷气流.
- 活跃的流量促进了增强的材料和/或信息传输.
- 纳米粒子表现出超扩散,受细菌集体反应的影响.
- 一小部分长长的细菌触发了流过渡,并在抗生素压力下增强了超扩散.
结论:
- 细菌的集体行为对于适应环境变异至关重要.
- 修改流体动力学和增强运输是关键的生存策略.
- 长长的细菌在人口层面适应压力方面发挥着重要作用.
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