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血管化的人类大脑器官在芯片上
Sin Yen Tan1, Xiaohan Feng1, Lily Kwan Wai Cheng2
1Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong. angelawu@ust.hk.
Lab on a chip
|May 31, 2023
概括
大脑有机体为人类大脑发育提供了一个窗口,但缺乏血管系统. 微流体可以通过启用输液和血脑屏障来增强这些模型,从而提高它们对研究的有用性.
科学领域:
- 神经科学是一个神经科学.
- 生物工程是生物工程.
- 发展生物学 发展生物学
背景情况:
- 由于复杂的细胞和结构特征,人脑的体外建模是复杂的.
- 大脑器官模仿人类大脑发育,但缺乏功能性血管系统.
- 微流体学为血管化大脑器官提供了潜在的解决方案.
研究的目的:
- 审查最先进的体外人类大脑模型.
- 探索微流体策略,通过血管系统增强大脑器官.
- 讨论血管化大脑器官发育的挑战和未来方向.
主要方法:
- 审查关于大脑器官和微流体系统的现有文献.
- 分析将微流体纳入大脑器官培养的策略.
- 讨论人类大脑在体内发育的比较背景.
主要成果:
- 目前的大脑器官缺乏必要的血管输液.
- 微流体设备可以引入血管化并控制血脑屏障的微环境.
- 微流体的整合为先进的大脑器官模型提供了一个有希望的途径.
结论:
- 血管化大脑器官对于准确的生理和病理建模至关重要.
- 微流体是克服目前大脑器官发育局限性的关键技术.
- 需要进一步的研究来解决障碍,并优化基于微流体的血管化大脑器官.
相关概念视频
00:49The Blood-brain Barrier
Overview
01:14Brain Imaging
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).