在COVID-19后的神经炎症与持续的抑郁和认知症状
Joeffre Braga1,2,3, Mariel Lepra1,2,3, Stephen J Kish1,2,3,4
1Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
这项研究发现,在COVID-19后经历持续抑郁和认知症状的个体中,增加了炎症性大脑变化 - - 质症. 这种神经炎症,特别是在腹上条纹体和背上膜中,可能解释了疲劳和无情感等持续症状.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 持续的抑郁和认知症状,称为COVID-DC,在COVID-19感染后很常见.
- 炎症性脑部变化 - - 质病 - - 被怀疑是COVID-DC,但以前没有得到量化.
- 转位蛋白总分布体积 (TSPO VT) 是一种正电子发射断层扫描 (PET) 标记器,用于化.
研究的目的:
- 为了调查TSPO VT是否在COVID-DC患者的特定大脑区域升高.
- 评估TSPO VT在背,腹,前额皮质,前带皮质和海马.
主要方法:
- 一项涉及20名COVID-DC参与者和20名健康对照者的病例控制研究.
- 使用[18F]FEPPA PET扫描进行TSPO VT测量.
- 用神经心理和心理测试来评估症状,重点关注条纹功能.
主要成果:
- 与对照人群相比,COVID-DC患者在所有研究的大脑区域中显示出显著更大的TSPO VT.
- 升高的TSPO VT在腹状条纹体 (22%更高) 和背部干 (20%更高) 中最为明显.
- 在COVID-DC患者中,较慢的运动速度与较高的背部骨相关 TSPO VT.
结论:
- 在COVID-DC患者中提升TSPO VT提供了大脑化增加的证据.
- 这种神经炎症,特别是在腹上条纹体和背上膜中,可能是持续的抑郁和认知症状的基础.
- 研究结果表明,COVID-19后的神经和精神疾病后果的潜在生物机制.
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