在患有无氧皮肤炎的成年人中发生静脉血栓栓塞的风险
Tai-Li Chen1,2, Wan-Ting Huang3, Ching-Hui Loh4,5
1Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.
JAMA dermatology
|May 31, 2023
概括
患有阿托皮性皮肤炎 (AD) 的成年人患有静脉血栓塞栓症 (VTE) 的风险增加. 虽然绝对风险很小,但建议在阿尔茨海默病患者中保持对VTE症状的警.
科学领域:
- 皮肤病学 皮肤病学
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 亚托皮炎 (AD) 与全身炎症和血管影响有关,这引发了关于其与心血管并发症相关性的疑问.
- 成年人的亚托皮肤炎和发生的静脉血栓塞栓症 (VTE) 之间的关系在很大程度上仍未得到研究.
研究的目的:
- 调查成年人的亚托皮性皮肤炎 (AD) 与发生静脉血栓塞栓症 (VTE) 的风险之间的关联.
主要方法:
- 一项基于人口的全国性队列研究利用了来自国家医疗保险研究数据库的数据.
- 在2003-2017年期间新诊断的AD的成年人 (≥20岁) 与没有AD的匹配对照进行了比较.
- 考克斯回归模型估计了VTE的危险比率 (HRs),分析按年龄和性别分层,以及不包括全身类固醇使用者的灵敏度分析.
主要成果:
- 这项研究包括284,858名参与者 (142,429人患有AD).
- 与没有AD的成年人相比,患有AD的成年人表现出发生VTE的风险显著增加 (HR,1.28;95% CI,1.17-1.40).
- 阿尔茨海默病与深静脉血栓症 (HR,1.26) 和肺栓塞 (HR,1.30) 的风险较高有关.
结论:
- 成人发病的亚托邦性皮肤炎与静脉血栓栓塞的风险增加有关.
- 在AD患者中,VTE的绝对风险增加是适度的,但建议在有症状的个体中对心血管评估进行临床考虑.
- 需要进一步的研究来了解AD和VTE连接的潜在病理生理学.
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