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脂肪肝,肝硬化和肝癌研究 (TENDENCY):一个多中心病例控制研究的协议

Yaqza Hussain¹, Ayman Bannaga¹, Neil Fisher²

¹University Hospitals Coventry & Warwickshire, Coventry, United Kingdom.

JMIR research protocols

|May 31, 2023

概括

这项研究调查了早期肝细胞癌 (HCC) 检测的新型非侵入性生物标志物. 验证甲基化septin 9,挥发性有机化合物和旨在改善肝癌患者的查.

科学领域:

肝病学和瘤学肝病学和瘤学
生物标志物发现发现
诊断研究研究诊断研究

背景情况:

肝细胞癌 (HCC) 的死亡率很高,需要改进早期检测方法.
目前的HCC查工具,包括α胎蛋白和超声波,具有有限的灵敏度.
肝硬化患者,特别是非酒精性脂肪肝和病毒性肝炎患者,患HCC的风险较高.

研究的目的:

为了验证肝细胞癌 (HCC) 诊断的新型非侵入性查标志物.
评估甲基化隔膜9,尿液挥发性有机化合物和尿液作为潜在的HCC生物标志物.
在肝病管理的背景下研究这些生物标志物.

主要方法:

采用了一个多中心,嵌套的病例控制研究设计.
在HCC病例和肝硬化对照之间比较了血甲基化隔膜蛋白9水平.
用先进的光谱技术分析尿液样本以检测HCC特有的挥发性有机化合物和.

主要成果:

为TENDENCY研究招募参与者于2023年3月结束.
该研究目前正在进行数据分析,预计将于2023年11月完成.

结论:

肝细胞癌的有效查测试仍然是一个关键的未满足的需求.
敏感的血和尿路生物标志物的整合可以提高早期HCC检测.
通过新型生物标志物的提前检测有潜力显著改善HCC患者的治疗结果.

关键词:

肝硬化是肝硬化的一种疾病.脂肪肝是一种脂肪肝.脂肪肝是一种脂肪肝疾病.肝炎肝炎是什么意思肝炎肝炎是什么意思肝细胞癌是一种肝细胞癌.肝癌肝癌是一种肝癌.甲基化隔膜 9 9 尿路酸在尿路酸.尿液中的挥发性有机化合物

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