在患有自发性肺胸腺瘤的患者中临床隐藏的扩散性多层层层层瘤
Daffolyn Rachael Fels Elliott1, Kristine E Konopka2, Steven M Hrycaj2
1Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, US.
American journal of clinical pathology
|May 31, 2023
概括
扩散性多层层层瘤 (DPM) 可以表现为未被怀疑的肺胸,特别是在老年患者中. 在这种情况下,组织学检查和辅助标记对于早期DPM检测至关重要.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 扩散性多层层层瘤 (DPM) 是一种罕见的恶性瘤.
- 自发性肺胸炎是一种常见的疾病,通常通过手术治疗.
- 早期发现DPM对于患者的治疗结果至关重要.
研究的目的:
- 在肺胸病患者的手术样本中调查未被怀疑的DPM的组织学特征.
- 在此背景下,评估辅助标记在诊断DPM中的实用性.
- 探索肺胸是否是位子间皮瘤 (MIS) 的临床表现.
主要方法:
- 对自发性肺胸部 (n=229) 和/或DPM (n=88) 患者的单一机构数据库 (2000-2020) 的回顾性审查.
- 对手术样本进行分析,以检测DPM的组织学特征.
- 免疫组织化学 (BAP-1,MTAP) 的应用以支持诊断.
主要成果:
- 两例 (2.3%) DPM最初呈现为自发性肺胸部,没有先前的怀疑.
- 这占所有肺胸外科手术的0.9%,在70岁以上的患者 (12.5%) 中更高.
- 免疫组织化学证实了DPM;一个MIS病例被追溯确定,在侵入性DPM之前25个月.
结论:
- 用辅助测试对血栓切除的组织学检查对于早期检测DPM至关重要.
- 自发性肺胸作为MIS的临床表现的作用需要进一步调查.
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