在机械通风过程中输送多种药物气溶
Ann D Cuccia1, Michael McPeck2, Janice A Lee2
1Respiratory Care Program, School of Health Professions, Stony Brook University, Stony Brook, New York, USA.
概括
在重症患者中,同时使用连续雾化和玻尿酸注射进行气溶输送是可行的. 喷气式和网状雾化器系统都允许在不切断电路的情况下进行双重气溶注射,尽管网状系统可能需要对中断进行监控.
科学领域:
- 临界护理医学 临界护理医学
- 呼吸系统疗法 呼吸系统疗法
- 气溶科学 气溶科学
背景情况:
- 肺血管扩张剂通常通过连续雾化对被直管的患者进行非标签的注射.
- 当需要额外的气溶剂药物 (例如支气管扩展剂,抗生素) 时,可以中止血管扩展剂治疗.
- 现有的气溶系统可能无法同时提供多种疗法,而不会影响治疗的连续性.
研究的目的:
- 通过连续雾化和玻璃注射,评估设计用于同时输送两个气溶的气溶系统的可行性和性能.
- 评估这些系统是否可以在不中断或断开呼吸回路的情况下运行.
- 为了比较双端口呼吸增强喷气雾化器 (BEJN) 和堆叠振动网状雾化器 (VMNs) 的吸入质量传递特性.
主要方法:
- 一个i-AIRE双端口呼吸增强喷气雾化器 (BEJN) 和两个Aerogen® Solo振动网状雾化器 (VMNs) 被测试.
- VMN被配置为一个堆叠的安排,用于连续输注和玻尿酸输送.
- 放射性标记盐水被用来量化吸入的质量 (注射器初始活性的%) 在不同的呼吸模式和输送模式下,在4小时的输液期间.
主要成果:
- 在BEJN和VMN系统中,喷雾剂药物的持续输注是线性的和可预测的.
- 在整个研究期间,BEJN在没有事故的情况下运行.
- 在连续 (38%) 和玻尿酸 (19%) 输送模式中,VMN系统经历了自发性中断,这些中断通过点击来解决;玻尿酸输送给出了VMN相比BEJN的更高的吸入质量百分比.
结论:
- 同时连续和玻璃气溶雾化无需电路断开,可以通过喷气式和网状雾化器技术实现.
- BEJN 显示出可靠的性能,而 VMN 可能需要监控,因为潜在的自发中断.
- 这些发现支持开发综合性气溶输送系统,用于重症患者的复杂治疗方案.
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