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组织温度,腔化和位移成像在聚焦超声波神经超声波处理期间的相互依赖性

Erica P McCune, Stephen A Lee, Elisa E Konofagou

IEEE transactions on ultrasonics, ferroelectrics, and frequency control

|May 31, 2023

概括

组织温度显著影响聚焦超声波 (FUS) 对神经的影响. 较高的温度增加了洞腔和神经位移,影响了FUS神经调节的安全性和效率.

科学领域:

生物医学工程生物医学工程
声学声学在声学方面
神经科学是一个神经科学.

背景情况:

聚焦超声波 (FUS) 外围神经调节与由于声波辐射力的神经位移有关.
化和温度积累在FUS神经调节中的作用仍然不清楚.
温度会影响组织粘弹性,影响化值,但体内效应尚不清楚.

研究的目的:

为了研究组织温度在FUS期间对化和神经位移的体内影响.
探索FUS神经调节过程中温度,腔位和组织位移之间的关系.
评估FUS安全性和效率的同时监测化和位移的潜力.

主要方法:

小鼠的坐骨神经在不同的基线温度 (30°C与38°C) 上使用FUS进行了超声波.
洞腔和组织位移同时通过被动洞腔成像和位移成像进行映射.
进行了组织学分析,以评估组织损伤,例如红细胞扩散.

主要成果:

与30°C相比,化水平在38°C时增加1.8-4.5dB.
在较高的基线温度下,组织位移也显著增加.
在惯性化剂量和位移成像噪声之间观察到强烈的正相关性.

结论:

在FUS过程中,组织温度调节了体内化和组织移位.
洞腔和组织位移是正相关的,这表明位移成像可以检测洞腔.
在FUS期间监测组织温度和腔位对于确保神经调节的安全性和效率至关重要.

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