在阿片类药物相关死亡之前的药物处方 - - 在法医尸检患者的注册研究
Jonatan Walde1, Lisa Andersson2, Björn Johnson2,3
1Umeå University and Region Västerbotten, Umeå, Sweden.
PloS one
|May 31, 2023
概括
处方阿尔普拉佐拉姆和迪亚泽帕姆与有药物使用史的个体的死亡有关. 建议在给有风险的患者处方这些药物时谨慎使用,以减少与阿片类药物相关的死亡率.
科学领域:
- 法医毒理学 法医毒理学
- 公共卫生 公共卫生
- 药物监督 药物监督 药物监督
背景情况:
- 尽管有干预措施,阿片类药物过量死亡人数在全球范围内仍在上升.
- 心理健康和处方药模式与阿片类药物死亡率有关.
- 需要进一步的研究来理解和扭转这一趋势.
研究的目的:
- 调查在生命最后六个月处方的药物,对于那些死于血液中阿片类药物的非法物质使用史的人来说.
- 检查处方药和死亡时血液中发现的药物之间的关系.
- 确定特定药物处方是否暂时与死亡有关.
主要方法:
- 追溯的,基于登记的观察性研究.
- 利用来自国家法医,药物处方注册表和社会服务的数据.
- 采用条件后勤回归来分析药物发放和死亡时间之间的时间关联.
主要成果:
- 开处方和开放阿尔普拉佐拉姆和迪亚泽帕姆显示了与死亡的时间联系.
- 常发行的药物包括佐皮克隆,普雷加巴林,甲基酸盐,西巴姆和氧化.
- 甲,阿尔普拉佐拉姆和布普伦诺芬在血液中最常见;阿片类药物和镇静剂的组合是常见的,通常与非法使用有关.
结论:
- 在有非法物质使用史或同时使用阿片类药物的患者中,开处方阿尔普拉佐拉姆和泽需要非常小心.
- 这些发现突出了与脆弱人群中的特定处方模式相关的潜在风险.
- 这项研究强调需要仔细监测和处方实践,以减轻与阿片类药物相关的死亡率.
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