恐惧灭绝依赖于由杏仁体塑造的腹部海马安全代码
Robin Nguyen1, Konstantinos Koukoutselos1, Thomas Forro1
1Laboratory of Systems Neuroscience, Department of Physiology, University of Bern, Bern, Switzerland.
Science advances
|May 31, 2023
概括
恐惧灭绝记忆依赖于腹部海马形成背景和安全的表示. 底侧杏仁体指导这个过程,这对于回忆学习的安全线索至关重要.
科学领域:
- 神经科学是一个神经科学.
- 记忆研究 记忆研究
- 恐惧的调节 恐惧的调节
背景情况:
- 空间上下文影响灭绝记忆检索.
- 情感价值在记忆选择的上下文表示中的作用尚不清楚.
研究的目的:
- 调查在恐惧灭绝记忆形成过程中,上下文表示是否会获得情感价值.
- 确定底侧杏仁体 (BLA) 和腹部海马体 (vH) 在这个过程中的参与.
主要方法:
- 活动依赖的Engram标签.
- 在体内从腹部海马体 (vH) 的单个单元电生理记录.
- 在恐惧灭绝学习过程中,基底侧杏仁体 (BLA) 输入的光遗传学操纵.
主要成果:
- 在vH中与条件刺激 (CS) 相关的活动在睡眠期间重新激活,并在恐惧灭绝期间恢复时加强.
- 恐惧灭绝记忆通过在灭绝背景下精确编码情感区域而得到改善.
- 这些模式和记忆检索取决于从BLA传输的谷氨酸.
结论:
- 恐惧灭绝记忆的形成涉及到vH中的上下文和刺激安全表示.
- 底侧杏仁体 (BLA) 在灭绝学习过程中指导这些表示.
- 语境情感编码支持恐惧灭绝记忆巩固和检索.
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