相关实验视频
Updated: Jul 28, 2025

08:09
A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
Published on: June 7, 2018
9.8K
达帕格利弗洛辛可能会防止多克索鲁比辛诱导的心脏毒性
Sebahat Ulusan1, Kanat Gülle2, Ahmet Peynirci3
1Faculty of Medicine, Isparta Süleyman Demirel University, Isparta, Turkey.
Anatolian journal of cardiology
|May 31, 2023
概括
达帕格利弗洛辛可能会防止多克索鲁比诱导的心脏毒性. 这项研究发现,在接受多克索鲁比治疗的老鼠中,达帕格利弗洛辛减少了心脏损伤标志物,改善了心脏功能,这表明它具有心脏保护作用.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 多克索鲁比是一种重要的化疗剂,但会导致剂量限制性心脏毒性.
- 达帕格利弗洛辛是一种抗糖尿病药物,具有潜在的心脏保护性质.
- 调查达帕格利弗洛辛减轻多克索鲁比诱导的心脏损伤的能力至关重要.
研究的目的:
- 评估达帕格利弗洛辛对多克索鲁比诱导心脏毒性的心脏保护作用.
- 为了评估结合治疗后的心脏功能和组织病理变化.
- 为了确定达帕格利弗洛辛是否可以减轻化疗相关的心脏损伤.
主要方法:
- 40只雄性Wistar白色老鼠被分配到四个组:对照组,达帕格利弗洛辛,多克索鲁比辛和多克索鲁比辛+达帕格利弗洛辛.
- 多克索鲁比辛 (15 mg/kg) 通过腹膜内给药,而达帕格利弗洛辛 (10 mg/kg) 则每天通过腹膜给药.
- 用心声图和心电图来评估心脏功能,并在六周后补充了他的病理学分析.
主要成果:
- 德克索鲁比辛治疗显著减少了15%的射出分数,这种效应被达帕格利弗洛辛减弱了.
- doxorubicin 增加了 QRS 持续时间 (65%) 和修正了 QT 持续时间 (12%),而 dapagliflozin 显著减少了这些增加 (分别为 7% 和 2%).
- 组织病理学揭示了多克索鲁比辛组的严重髓溶解,炎症和亡,在达帕格利弗洛辛联合治疗组中是最小的.
结论:
- 达帕格利弗洛辛在减少多克索鲁比诱导的心脏毒性方面显示出显著的潜力.
- 这些发现表明,达帕格利弗洛辛可以保持心脏功能并减轻组织病理损伤.
- 达帕格利弗洛辛可能是一种有价值的辅助疗法,可以在多克索鲁比辛治疗期间保护心脏.
相关概念视频
Dipeptidyl Peptidase 4 Inhibitors
216
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
216
Oral Hypoglycemic Agents: Biguanides and Glitazones
241
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
241
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
471
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
471
Heart Failure Drugs: Inotropic Agents
644
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
644
Oral Hypoglycemic Agents: Glinides
190
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
190
Insulin: Dosing Regimen and Adverse Effects
217
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
217

