审查SARS-CoV-2的神经学表现的审查
Priyal1, Vineet Sehgal2, Saniya Kapila3
1Neurology, Indraprastha Apollo Hospitals, New Delhi, IND.
Cureus
|May 31, 2023
概括
严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 通过内皮病变和细胞因子风暴引起各种神经疾病,而不是直接侵入中枢神经系统. 自体免疫驱动长期的神经COVID-19后果.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 神经免疫学 神经免疫学
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染与影响中枢和外围神经系统的广泛神经症状有关.
- 神经系统疾病包括脑病变,,中风,脑神经麻,骨髓炎,吉林巴雷综合征和神经肌肉疾病.
- 病理生理学有所不同,急性疾病可能是由内皮质变异和细胞因子风暴驱动的,而COVID-19后的后续可能涉及自身免疫和分子模仿.
研究的目的:
- 审查与SARS-CoV-2感染相关的神经症状.
- 阐明神经COVID-19的潜在致病机制.
- 描述疾病和各种神经系统并发症的根本原因.
主要方法:
- 在Pubmed/Medline和Google Scholar的系统文献搜索中,使用关键字"SARS-CoV-2"和"神经疾病"查找2020年1月至2022年11月期间发表的文章.
- 使用SWIFT-Review文本挖掘工作台将1383个检索的文章分类为MeSH等级树代码.
- 精选152篇文章的全文审查.
主要成果:
- 检测到SARS-CoV-2RNA在大脑区域没有显著的组织病理变化;注意到中枢神经系统炎症,特别是在嗅球和脑干.
- 在大脑组织中发现的病毒基因组和蛋白质,但神经病理变化很少发生.
- 大多数患有神经症状的患者在神经系统中缺乏活跃的病毒复制;内皮病和全身炎症是神经COVID-19的关键驱动因素.
结论:
- 神经COVID-19的发病过程涉及内皮病变和系统性炎症反应,由促炎细胞因子介导.
- 系统性炎症媒介可能间接激活中枢神经系统的免疫细胞 (星细胞,微质细胞),导致组织损伤.
- 病毒直接透到中枢神经系统还没有被明确证明.
更多相关视频
相关概念视频
Neural Regulation
39.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.6K
Disorders of the Nervous Tissue
1.4K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.4K
Aneurysm II: Clinical Manifestations and Diagnostic Studies
11
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
11
Cranial and Spinal Meninges
1.6K
The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
1.6K
Parkinson's Disease: Overview
614
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
614
Seizures: Classification
451
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
451


