描述相变纳米滴的化学和物理特性
Weiqi Zhang1, Hilde Metzger2, Stavros Vlatakis1
1Institute of Cancer & Pharmaceutical Sciences, King's College London, United Kingdom.
Ultrasonics sonochemistry
|May 31, 2023
概括
在相变纳米滴中量化完全化碳含量对于超声波治疗学至关重要. 一种新的19F核磁共振方法准确地测量了 perfluorocarbon 度,有助于纳米液滴的发展和表征.
科学领域:
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
背景情况:
- 阶段变换纳米滴正在成为超声波透视纳米粒子,在组织分布中比微泡具有优势.
- 这些纳米液滴由稳定和高碳核组成,在暴露于超声波时能够蒸发成回声微泡.
研究的目的:
- 开发和验证用于量化纳米滴中 perfluorocarbon 核心含量的方法.
- 为了确定信号和 perfluorocarbon 度之间的相关性,以便准确量化.
- 为了评估制造的纳米滴的稳定性和化特性.
主要方法:
- 使用脂质外和 perfluorocarbons制造纳米滴.
- 使用19F核磁共振 (NMR) 和富里埃转换红外光谱法 (FTIR) 量化完碳核心.
- 通过超声波传感器 (1.1MHz) 和高速摄像头成像来评估化.
主要成果:
- 19F核磁共振显示了信号与 perfluorocarbon 度之间的准确相关性.
- 开发的NMR方法成功量化了纳米滴中的高碳核含量.
- 与 perfluorohexane 纳米滴相比, perfluoropentane 纳米滴表现出更快的内容损失.
- 高速成像证实了纳米滴产生与商业微泡相比较的洞穴.
结论:
- 精确量化高碳含量对于理解和优化纳米液滴相变特性至关重要.
- 基于19F核磁共振的方法为评估纳米滴中的 perfluorocarbon 度提供了一个可靠的工具.
- 这种量化对于纳米滴体治疗学的进步和临床转化至关重要.
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