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树突细胞疫苗接种治疗癌症的进展

Sajad Najafi¹, Keywan Mortezaee²

¹Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

|May 31, 2023

概括

使用树突细胞 (DC) 的抗癌疫苗显示出希望,但面临挑战. 像将DC疫苗与免疫检查点抑制剂 (ICI) 结合在一起的策略正在探索,以提高它们对抗癌症的有效性.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
疫苗学疫苗学疫苗学

背景情况:

预防性疫苗在历史上消除了疾病并挽救了生命.
抗癌疫苗对人类健康至关重要,但需要优化.
树突细胞 (DCs),强大的抗原呈现细胞 (APCs),是瘤免疫疗法的关键.

研究的目的:

审查目前关于树突细胞 (DC) 疫苗接种的实验和临床试验,以检查抗癌疗效.
专注于提高DC疫苗在癌症治疗中的潜力.

主要方法:

对癌症中DC疫苗接种策略的现有文献的审查.
分析导致DC疫苗失效的因素,包括免疫抑制瘤微环境 (TME) 和检查点蛋白.
探索组合疗法,例如免疫检查点抑制剂 (ICI).

主要成果:

DC疫苗接种策略,包括用瘤抗原脉冲DC,在临床前和临床癌症试验中显示出一些有希望的结果.
对DC疫苗有效性的挑战包括免疫抑制性TME,检查点蛋白过度表达,低于最佳的T细胞狂热度和缺乏辅助剂.
与ICI结合治疗是一种有前途的策略,可以克服这些局限性.

结论:

DC疫苗接种具有作为抗癌治疗策略的潜力.
需要进一步优化,以克服当前DC疫苗方法的局限性.
组合疗法,特别是ICI,是改善抗癌DC疫苗疗效的重要途径.

关键词:

癌症,免疫检查点抑制剂 (ICI),编程死亡-1 (PD-1),瘤微环境 (TME).树突细胞 (DC) 是一种干细胞.疫苗接种疫苗接种

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