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在接受肝移植的急性或慢性肝衰竭患者中,SPP1是风险因素

Yeping Yu¹, Xinyi Mao², Jieying Wang³

¹Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Central Laboratory, Department of Liver Diseases, ShuGuang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine, Shanghai, China.

International immunopharmacology

|May 31, 2023

概括

分泌的蛋白1 (SPP1) 可以预测急性或慢性肝衰竭 (ACLF) 患者接受肝移植 (LT) 的结果. 升高的SPP1水平表明生存率较差,这表明其在临床评估中使用.

科学领域:

肝病学和移植免疫学
分子诊断和生物标志物分子诊断
系统生物学在疾病中的应用

背景情况:

急性慢性肝衰竭 (ACLF) 呈现高死亡率和可变的预后,需要改善肝移植 (LT) 的评估.
系统性炎症是ACLF的标志,影响患者的治疗结果和治疗策略.

研究的目的:

为了确定新的生物标志物来预测经过LT的ACLF患者的结果.
评估循环蛋白质作为ACLF疾病严重程度和生存指标的潜力.

主要方法:

在ACLF患者和对照中对周围血液单核细胞 (PBMC) 和肝脏CD45+T细胞进行转录组分析.
使用回顾性 (n=137) 和前性 (n=68) 队列确定候选生物标志物的验证.
生物标志物水平与临床参数的相关性分析,如肝衰竭,凝血状态和LT后的存活率.

主要成果:

分泌的蛋白1 (SPP1) 被确定为接受LT的ACLF患者的潜在指标.
升高的SPP1水平与增加的疾病严重程度,肝衰竭和凝血失败相关.
在非幸存者中,LT前SPP1水平明显高于90天内幸存者.
与单独的MELD和CLIF-C ACLF得分相比,SPP1-MELD和SPP1-CLIF-C ACLF得分显示出更高的预测准确性.

结论:

循环SPP1显示显著的希望作为一个预测生物标志物对经过LT的ACLF患者.
SPP1水平可以帮助评估ACLF患者移植后的临床结果和生存预后.
监测SPP1可能会提高ACLF的临床决策和患者管理.

关键词:

慢性肝衰竭中的急性肝衰竭.指标指标指标指标指标指标指标肝脏移植肝脏移植 SPP1 SPP1 这是一个很好的选择.

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