孕产妇补充的黑激素塑造了肠道微生物群,并保护了生命早期的炎症
Fei Li1, Jiahao Lai1, Fei Ma2
1Department of Pediatrics, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China; Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education, China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University.
International immunopharmacology
|May 31, 2023
概括
孕产妇服用黑素补充剂会积极影响生命早期的肠道微生物群组成,并增强有益细菌. 这种干预措施还可以保护新生小鼠免受炎症和肠道损伤.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
背景情况:
- 肠道微生物群对于免疫发育和新陈代谢至关重要.
- 黑色素通过调节肠道失生症来显示治疗潜力.
- 黑激素对早期肠道微生物群殖民的作用尚不清楚.
研究的目的:
- 为了研究母亲补充黑激素对生命早期肠道微生物群殖民化的影响.
- 评估黑激素对新生小鼠的炎症和肠道损伤的保护作用.
主要方法:
- 小鼠在孕期和哺乳期接受了黑激素.
- 在分娩后的几天分析了肠道微生物群的组成.
- 测量了黑色素和短链脂肪酸度.
- 脂多糖 (LPS) 用于诱导炎症和评估肠道损伤.
主要成果:
- 孕产妇的黑激素显著增加了新生小鼠的内皮和结肠微生物群中的Firmicutes的丰富性.
- 补充美拉托尼增加了肠道光中的美拉托尼和便中的黄油酸度.
- 氨酸和甲酸盐治疗都减轻了肠道损伤并减少了炎症因素.
结论:
- 母亲补充的黑激素塑造了后代的肠道微生物群和新陈代谢.
- 黑素在生命早期提供对LPS诱导的炎症的保护.
- 这突显了黑激素在早期健康方面的潜在作用.
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