在帕金森病中对失调睡眠的共识睡眠阶段评分的评估
Leslie C West1, Michael Summers2, Siqun Tang3
1University of California San Francisco, Department of Neurology, USA.
Sleep medicine
|May 31, 2023
概括
在帕金森病 (PD) 中准确地确定睡眠阶段是具有挑战性的. 一种新的共识评分方法使睡眠阶段的一致性提高到96.58%,有助于PD研究.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 生物医学工程 生物医学工程
背景情况:
- 睡眠障碍在帕金森病 (PD) 中很常见,可能与基底状皮质电路功能障碍有关.
- 准确的睡眠阶段确定对于研究PD相关睡眠问题至关重要,但在这个人群中存在挑战.
- 临床试验中睡眠分阶段的现有方法可能会受到分阶段间变化的影响.
研究的目的:
- 为了优化睡眠分阶段的共识,并减少晚期帕金森病 (PD) 患者的interrater变化.
- 建立一个可靠的方法来确定睡眠阶段在一个多站点的临床试验中,涉及PD患者的脑下核深度大脑刺激 (STN-DBS).
主要方法:
- 利用视频多梦图 (vPSG) 数据从15名PD受试者超过45个晚上.
- 实施了两阶段的评分过程:最初的独立评分,然后对不一致的时代进行二次共识审查.
- 不一致的时代通过重新评估来解决,包括直接测量皮质活动,生理上下文和视频审查.
主要成果:
- 最初的睡眠阶段评分协议平均为83.10%.
- 二级共识得分显著提高了达成一致的比例,达到96.58%.
- 在区分清醒和N2睡眠阶段时出现了最大的分歧,这些分歧通过详细分析来解决.
结论:
- 与传统标准相比,开发的多层次共识评分方法实现了优越的协议.
- 这种方法利用定制的vPSG软件,提高了PD多站点临床试验中睡眠阶段评分的可靠性.
- 优化的方法为未来对帕金森病睡眠调节障碍的研究提供了坚实的框架.
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