外部冷大气等离子体响应现场水凝用于重塑瘤免疫微环境
Junho Byun1, Yina Wu1, Jaiwoo Lee1
1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
Biomaterials
|May 31, 2023
概括
冷大气等离子体和一种新的水凝疗法有效地激活了抗瘤免疫反应. 这种方法重塑瘤的微环境,导致瘤的彻底切除和在临床前模型的长期存活.
科学领域:
- 生物医学工程 生物医学工程
- 免疫学 免疫学 免疫学
- 材料科学 材料科学 材料科学
背景情况:
- 免疫疗法受到免疫抑制性瘤微环境的限制.
- 冷大气等离子体 (CAP) 可以产生反应性氧物种并增强抗原呈现.
- 开发克服瘤免疫抑制的策略对于有效的癌症治疗至关重要.
研究的目的:
- 开发一个现场的水凝系统,在瘤微环境中持续提供纳米辅助剂.
- 为了研究CAP辐射和转化生长因子β阻断纳米辅助剂 (TLN) 装载水凝 (TLN@CHG) 对抗瘤免疫的联合作用.
主要方法:
- 内注射甲酸-氨酸合物,然后CAP照射以形成in-situ水凝.
- 将TLN纳入水凝微型网络 (TLN@CHG).
- 在CT26瘤携带小鼠中评估树突细胞激活,T细胞种群 (CD4+,CD8+),瘤切除和存活率.
主要成果:
- TLN@CHG治疗显著促进了树突细胞激活,并在瘤微环境中增加了CD4+和CD8+T细胞比例.
- CAP诱导的TLN@CHG疗法导致了完全的原发性瘤切除.
- 在与瘤细胞重新挑战的小鼠中观察到100%的存活率,这表明免疫记忆强大.
结论:
- 现场基于水凝的微网络,如TLN@CHG,可以有效地重塑瘤免疫微环境.
- 这种方法有望提高免疫疗法疗效.
- 水凝微网络概念可以扩展到其他纳米辅助剂,以持续治疗作用.
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