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孕产妇冠状病毒病对早产儿发病率的影响

Gökçe Çıplak¹, Cem Becerir¹, Fatma N Sarı¹

¹Department of Neonatology, Neonatal Intensive Care Unit, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Türkiye.

American journal of perinatology

|May 31, 2023

概括

怀孕期间母亲的COVID-19感染并没有显著影响大多数早产婴儿的发病率或死亡率. 然而,它被确定为在出生时体重非常低的婴儿中发展专利动脉管 (PDA) 的独立风险因素.

科学领域:

新生儿科学新生儿科学
孕产妇和胎儿医学孕产妇和胎儿医学
传染性疾病传染性疾病

背景情况:

怀有冠状病毒疾病 (COVID-19) 的怀孕可能会影响早产婴儿的健康,因为SARS-CoV-2的炎症性质.
暴露于子宫内炎症可能会导致早产儿的不良结果.
COVID-19对胎儿和新生儿健康的确切影响需要进一步调查.

研究的目的:

为了评估母体COVID-19对早产婴儿发病率的影响.
评估第三级新生儿重症监护室环境中的结果.

主要方法:

一项观察性队列研究比较了早产婴儿 (<37周妊娠年龄) 与没有母体COVID-19的情况.
从2020年3月到2021年12月收集的数据包括人口统计和临床结果.
包括254名婴儿 (母体COVID-19组127名,控制组127名).

主要成果:

最常见的早产发病率 (RDS,败血症,IVH,NEC,BPD,ROP) 和死亡率在各组之间相似.
亚组分析显示,在母亲感染SARS-CoV-2的婴儿 ≤1,500g (38%对15%,p=0.023) 中,动脉管 (PDA) 的发生率显著更高.
孕产妇COVID-19独立预测PDA在出生时体重非常低的婴儿 (OR3.4,p=0.031).

结论:

怀孕期间的COVID-19通常不会对早产婴儿整体发病率和死亡率产生不良影响.
母亲COVID-19是体重≤1,500克的早产婴儿PDA的重要危险因素.
需要进一步的研究,以充分阐明COVID-19对新生儿健康的影响.

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