芬兰的肺癌存活率在2007年至2019年期间没有改善 - - 一个单一中心回顾性基于人口的真实世界研究
Jarkko Ahvonen1,2, Tiina Luukkaala3,4, Tarja Laitinen5
1Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Acta oncologica (Stockholm, Sweden)
|May 31, 2023
概括
芬兰的肺癌存活率没有改善,五年存活率仍然停滞在17%左右. 这在很大程度上是由于晚期诊断的比例很高,强调了通过查和意识提前检测的必要性.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 康科德-3研究表明,在21世纪,芬兰的肺癌5年生存率停滞不前.
- 调查芬兰某一大学医院的生存趋势对于确定导致这种缺乏改善的因素至关重要.
研究的目的:
- 评估坦佩雷大学医院2007-2019年肺癌患者生存趋势.
- 为了确定预后因素和未变的生存率的潜在原因.
主要方法:
- 对3041名肺癌患者进行了以人口为基础的回顾性研究.
- 两个诊断队列的比较:2007-2012年和2013-2019年.
- 对生存时间和预后因素分布的时间变化的分析.
主要成果:
- 总体存活率和5年存活率在两个队列之间在统计学上保持不变 (中位数存活率为8.7与9.2个月;5年存活率为16.6%与17.8%).
- 第四阶段肺癌患者的比例 (约. 59%) 和他们的死亡风险在两个队伍中都是相似的.
- 死亡的独立风险因素包括男性性别,晚期和表现不佳状态;从不吸烟状态和突变与后期队列的风险降低有关.
结论:
- 芬兰的真实肺癌存活率在15年内没有改善,这反映了CONCORD-3的发现.
- 主要原因是晚期诊断的持续高比例.
- 通过查及早发现肺癌和提高公众意识是必不可少的.
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