铁亡信号通路:阿尔茨海默氏症的疾病
1Faculty of Pharmaceutical Sciences, Rama University, Kanpur, India.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
|May 31, 2023
概括
阿尔茨海默病涉及铁代谢,脂质过氧化和氧化应激,这是ferroptosis的关键因素,这是一个调节的细胞死亡. 了解铁亡途径可能会揭示神经退行性疾病的新治疗点.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 神经科学是一个神经科学.
背景情况:
- 阿尔茨海默氏病 (AD) 的发病包括铁代谢,脂质过氧化和氧化应激.
- 这些过程是ferroptosis的关键调节者,这是一种独特的受调节细胞死亡形式.
- 铁对于脂质过氧化是必不可少的,因为氧化酶 (LOXs) 催化了多不和脂肪酸 (PUFA) 的氧化.
研究的目的:
- 审查了解铁亡信号通路的最新进展.
- 探索铁代谢和脂质过氧化在铁亡中的作用.
- 讨论铁亡对包括阿尔茨海默病在内的各种疾病的影响.
主要方法:
- 关于铁亡信号通路的文献综述.
- 分析铁,脂氧酶 (LOX) 和酶如ACSL4,LPCAT3,ALOX和POR在铁亡中的作用.
- 讨论铁化剂 (德菲洛克萨明,德菲里) 作为潜在的治疗方法.
主要成果:
- 铁是ferroptosis的一个关键组成部分,直接参与通过LOXs的脂质过氧化.
- 诸如ACSL4,LPCAT3,ALOXs和POR等酶通过氧化PUFA来促进铁亡.
- 自性降解途径可以增加铁的积累和脂质过氧化,加剧铁亡.
结论:
- 铁亡是一种受调节的死细胞死亡途径,涉及癌症,神经系统疾病和缺血/再损伤.
- 大脑脊髓液 (CSF) 的费里丁可以作为大脑铁水平的生物标志物.
- 向铁亡途径为阿尔茨海默病和其他疾病提供了潜在的治疗策略.
相关概念视频
01:26Alzheimer's Disease: Overview
539
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
539
01:16Necrosis
4.6K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.6K
01:22Alzheimer's Disease: Treatment
226
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
226
03:14Notch Signaling Pathway
4.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.3K
03:03Amyloid Fibrils
9.6K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.6K
01:00Enzyme-linked Receptors
78.9K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
78.9K