冠状动脉疾病与心房功能受损有关,无论左心室的填充压力如何
Oleg F Sharifov1, Thomas S Denney2, Andrew A Girard1
1Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America.
International journal of cardiology
|May 31, 2023
概括
冠状动脉疾病 (CAD) 严重程度影响左心房 (LA) 应变,即使保留左心室射出分数 (LVEF). 肌功能障碍与CAD严重程度和酸盐使用有关,影响肌-肌相互作用.
科学领域:
- 心脏病学 心脏病学
- 心脏成像 - - 心脏成像
- 血液动力学 血液动力学
背景情况:
- 左心房 (LA) 应变在左心室 (LV) 扩张功能障碍中受损,与升高的LV终端-扩张压力 (LVEDP) 相关.
- 众所周知,冠状动脉疾病 (CAD) 会影响LV静脉透功能,这些患者有LV静脉射分数 (LVEF) 的保存.
- LVEDP,CAD之间的特定关系及其对LA菌株的影响仍未得到充分研究.
研究的目的:
- 为了研究冠状动脉疾病 (CAD) 严重程度和左心房 (LA) 应变参数之间的关联.
- 探索左心室末端透气压 (LVEDP) 和CAD对LVEF保存患者的LA功能的影响.
- 在CAD的背景下,评估酸盐等药物的对LA菌株的影响.
主要方法:
- 追溯分析37名LVEF>50%的患者进行冠状动脉血管造影,高准确度LV压力测量和心脏MRI.
- 量化LA体积,LA排空分数 (LAEF),LA储应变 (LARS) 和LA长轴缩短 (LALAS).
- 根据冠状动脉血管学发现,患者被分为严重的CAD,轻度至中度的CAD和无CAD组.
主要成果:
- 与没有CAD组相比,严重CAD组的LAEF,LALAS和LARS显著降低.
- 拉动脉储应变 (LARS) 和拉动脉长轴缩短 (LALAS) 与CAD严重程度和酸盐治疗有关.
- LA排空分数 (LAEF) 与CAD严重程度,酸盐治疗和LA最小体积有关;LAEF被动与LVED体积有关.
结论:
- 动脉功能障碍与同时存在的冠状动脉疾病 (CAD) 的严重程度有关.
- 药物,特别是酸盐和血液动力负荷条件影响LA应变评估.
- 这些因素对于理解LA功能和LA-LV相互作用至关重要,因此需要在更大的队列中进行进一步的研究.
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