在急性全身炎症期间的疲劳与减少精神努力支出有关,而任务准确性被保留
B I H M Lambregts1, E Vassena2, A Jansen3
1Department of Psychiatry, Radboud University Medical Center, Postbus 9101, 6500 HB Nijmegen, The Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Postbus 9104, HE Nijmegen, The Netherlands.
Brain, behavior, and immunity
|May 31, 2023
概括
急性疾病会导致疲劳,降低精神努力的意愿,类似于身体炼. 这表明炎症影响一般的努力分配,而不是特定的认知能力.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 免疫学 免疫学 免疫学
背景情况:
- 以前的研究表明,身体炎症会改变动机优先级和努力分配.
- 目前尚不清楚类似的动机框架是否解释了疾病期间的精神疲劳和认知症状.
研究的目的:
- 在急性系统性炎症期间调查疲劳,细胞因子和基于精神努力的决策之间的关系.
主要方法:
- 八十五名参与者接受了脂聚糖 (LPS) 管理后的精神努力任务.
- 测量了细胞因子水平 (IL-6,IL-8,TNF) 和疲劳.
- 使用通用估计方程 (GEE) 分析了决策接受率.
主要成果:
- 细胞因子度和疲劳在LPS后2小时增加.
- 对于中等难度的任务,尽管保持了准确性,但心理努力的接受率下降了.
- 减少接受与疲劳有关,而不是细胞因子水平.
结论:
- 在急性炎症期间的疲劳会改变精神劳动的分配,反映身体劳动的变化.
- 在疾病期间,精神努力的意愿受到努力水平的影响,而不是奖励.
- 这些发现支持了炎症延伸到认知努力的动机解释,影响了一般的分配过程.
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