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局部Cdr1as活动是需要的恐惧灭绝记忆.

Esmi Lau Zajaczkowski1, Qiongyi Zhao1, Wei-Siang Liau1

  • 1Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.

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概括

循环RNAs (circRNAs) 是调节记忆的关键大脑分子. 在突触中准与小脑退化相关的蛋白1反意义RNA (Cdr1as) 损害了恐惧灭绝记忆,显示circRNA.

关键词:
在Cdr1as.灭绝的灭绝 灭绝的灭绝恐惧 恐惧 恐惧 恐惧记忆 记忆 记忆 记忆 记忆突触体突触体是一个突触体突触体.环RNA 环RNA 是一个环RNA.

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科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 循环RNAs (circRNAs) 是在大脑中发现的稳定调节分子,特别是在突触处.
  • 环形RNA具有多种功能,包括微型RNA诱和蛋白质结合,有些是翻译的.
  • 以前的研究将circRNA与神经系统疾病联系起来,但它们在记忆中的作用仍然不清楚.

研究的目的:

  • 研究突触圆形RNAs在记忆形成中的作用.
  • 为了确定特定的circRNA是否参与恐惧灭绝记忆.

主要方法:

  • 从被训练在恐惧灭绝中的小鼠中枢前额叶皮层的突触体中分析circRNAs.
  • 识别突触丰富的circRNAs,包括Cdr1as.
  • 针对Cdr1as在下边皮层神经过程中的有针对性的打击.

主要成果:

  • 确定了12837个突触丰富的环RNAs.
  • 与大脑小脑退化相关的蛋白1反意义RNA (Cdr1as) 是已识别的circRNAs之一.
  • 击败Cdr1as导致恐惧灭绝记忆的受损.

结论:

  • 突触circRNA在记忆形成中起着至关重要的作用.
  • Cdr1as与恐惧灭绝记忆的调节有关.
  • 在突触处局部化的circRNA活动对记忆过程至关重要.