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精子分子甲基组及其对远鱼水温的敏感性

Aurélien Brionne¹, Anne-Sophie Goupil¹, Stéphanie Kica¹

¹INRAE, UR1037 LPGP, Fish Physiology and Genomics, Campus de Beaulieu, F-35000 Rennes, France.

The Science of the total environment

|May 31, 2023

概括

鱼类可能会将表观遗传变化传给后代,帮助它们快速适应变化的环境,比如变暖的水域. 精子DNA甲基化模式反映了父母的热应激,这表明鱼类的代际遗传机制.

科学领域:

表观遗传学和环境适应
水产养殖和鱼类生物学
遗传的分子机制的分子机制.

背景情况:

鱼类面临着气候变化和热浪等环境压力因素.
鱼类表现出可塑性和世代适应环境变化.
鱼类的表观遗传正在引起人们的兴趣,因为在哺乳动物中观察到的甲基组擦除不保留.

研究的目的:

为了研究鱼类是否可以通过性子细胞传递表观遗传变化给后代.
探索表观遗传在鱼类快速环境适应中的作用.
描述彩虹鱼的精子甲基组及其对热应激的反应.

主要方法:

在彩虹鱼中使用双硫酸盐测序进行精子 DNA 甲基化景观分析.
精子甲基组与肌肉组织的比较.
在精子生成过程中对精子甲基组的温度影响 (4°C增加) 的评估.

主要成果:

精子细胞甲基组为家庭和发育基因进行激活,这对早期发育至关重要.
大多数无甲基化促进剂不受温度升高的影响,显示出强度.
温度升高在5359个区域诱导了差异甲基化,其中包括560个参与精子生成和脂质代谢的基因促进物.

结论:

鱼类的精子表观遗传景观带有父母热暴露的痕迹.
精子中的DNA甲基化可能作为鱼类代际遗传的分子基础.
这表明了鱼群快速适应环境变化的潜在机制.

关键词:

通过DNA甲基化.鱼类鱼类鱼类鱼类继承权继承权继承权精子动物 (Spermatozoa) 是一种精子.温度温度是指温度.

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