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在成人默克尔细胞原始体中,默克尔细胞多瘤病毒T抗原介导重编程
Madison Weber1, Minh Binh Nguyen1, Meng Yen Li1
1Black Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
The Journal of investigative dermatology
|May 31, 2023
概括
在成年人皮肤中,SOX9表达细胞被确定为默克尔细胞的祖先. 这些细胞可以再生默克尔细胞,特别是在受伤后,并可能被默克尔细胞多重瘤病毒T抗原重新编程.
科学领域:
- 皮肤病学 皮肤病学
- 细胞生物学 细胞生物学
- 在瘤学瘤学.
背景情况:
- 成人的皮肤中梅克尔细胞的再生仍然不清楚.
- 默克尔细胞癌 (MCC) 是一种罕见的神经内分泌性皮肤癌,与默克尔细胞原始体和多细胞病毒有关.
研究的目的:
- 识别成人默克尔细胞的祖先.
- 调查它们形成MCC的潜力.
主要方法:
- 在产后小鼠皮肤中追踪血统.
- 对表达SOX9的细胞 (SOX9+细胞) 的分析.
主要成果:
- 被确定为默克尔细胞原始体的SOX9+细胞.
- 在成熟的皮肤中,再生很少发生,但在轻微的机械损伤时会增加.
- 默克尔细胞多重瘤病毒T抗原将SOX9+细胞重新编程为神经内分泌和默克尔细胞系.
结论:
- SOX9+细胞是产后的默克尔细胞的祖先.
- 这些祖先可以通过病毒T抗原重新编程,为MCC起源提供了洞察力.
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