阿斯伯吉勒斯 (Aspergillus welwitschiae) 是一种主要的奥托米科斯病原体,来自伊朗的新流行病学和抗真菌易感性数据
Marzieh Halvaeezadeh1, Gholam Ali Jalaee2, Mahnaz Fatahinia1
1Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Microbial pathogenesis
|May 31, 2023
概括
阿斯伯吉illus welwitschiae和阿斯伯吉illus tubingensis是致死菌的主要原因,其中A. welwitschiae对某些抗真菌药物,如卢利可纳和沃里可纳,表现出更大的敏感性.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 分子诊断学 分子诊断
背景情况:
- 黑色阿斯伯吉利 (Aspergillus section Nigri) 是导致奥托米科斯的关键原因,但物种差异化一直是具有挑战性的.
- 从历史上看,黑色虫被认为是主要的病原体,但最近使用calmodulin基因测序的研究确定了A. welwitschiae和A. tubingensis作为主要的病原体.
研究的目的:
- 通过使用卡尔莫杜林基因测序,将黑色阿斯伯吉利从奥托米科斯病例中分离和识别出来.
- 评估已识别的阿斯伯吉勒斯菌种的抗真菌易感性.
主要方法:
- 来自134名奥托米科斯患者的样本被培养,黑色阿斯伯吉利通过殖民地形态学,显微镜和calmodulin基因测序来识别.
- 根据CLSI M38第三版指南进行了抗真菌敏感性测试.
主要成果:
- 尼格里是最常见的真菌病原体,其中A.welwitschiae (60.5%) 和A.tubingensis (36.0%) 是最常见的物种.
- 与A.tubingensis.相比,A.welwitschiae对卢利可纳,沃里可纳和安福特里辛B的敏感性更高.
- 耐药性模式各不相同,有很大比例的A. welwitschiae菌株表现出对尼斯塔丁的非野生类型状态.
结论:
- 鉴定出A.welwitschiae是最常见的致病原体,其次是A.tubingensis,挑战了以前的分类.
- 观察到不同的抗真菌敏感性,A.welwitschiae更容易受到卢利可纳,沃里可纳和安福特瑞辛B的作用,而A.tubingensis对伊特拉可纳更敏感.
- 在这两种物种之间,发现了明显的耐药性,特别是对尼斯塔丁和安福特里辛B的耐药性.
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