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丁昆药在小鼠中通过调节PTEN/PI3K/AKT/FOXO3a信号通路来调节化疗诱导的过早卵巢功能

Chan Su¹, Ruihong Zhang², Xiujuan Zhang¹

¹Department of Gynecology and Obstetrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, PR China.

Journal of ethnopharmacology

|May 31, 2023

概括

丁昆丸通过调节PTEN/PI3K/AKT/FOXO3a通路,改善了过早卵巢衰竭 (POI) 的小鼠的卵巢功能. 中等剂量在促进卵泡生长和排卵方面表现更好.

科学领域:

生殖生物学生殖生物学
药理学药理学是指药理学的学科.
传统中国医药传统中国医药

背景情况:

丁昆药 (DKP) 是一种传统的中医药,具有众所周知的生殖益处.
在治疗早产卵巢衰竭 (POI) 中,DKP的确切机制尚不清楚.

研究的目的:

为了评估不同剂量的DKP对卵功能在循环胺 (CTX) 诱导的POI小鼠的疗效.
阐明涉及PTEN/PI3K/AKT/FOXO3a信号通路的分子机制.

主要方法:

在ICR小鼠中使用CTX建立POI模型.
小鼠接受了21天的低,中或高剂量的DKP治疗.
评估体重,雌性周期,卵巢指数,血清激素水平 (FSH,LH,E2,AMH),卵巢组织学,以及分子通路蛋白质/基因表达 (PTEN,PI3K,AKT,FOXO3a).

主要成果:

DKP治疗改善了体重,雌性周期,卵巢指数和卵巢形态.
荷尔蒙平衡受到调节,在特定剂量下降FSH/LH和增加E2.
用低剂量/中剂量改善毛囊生长,而用高剂量显著增加黄体.
DKP提高了PTEN的调节,抑制了p-PI3K/p-AKT,并抑制了p-FOXO3a,特别是在中等剂量时.

结论:

在POI小鼠模型中,DKP有效调节激素水平,促进卵泡发育,并诱导排卵.
低至中等剂量的DKP显示出最佳的治疗效果.
该机制涉及PTEN/PI3K/AKT/FOXO3a信号通路的调节.

关键词:

环酸胺的使用方法丁昆药丸是一种药丸.这就是FOXO3a.在这里,我们可以看到PTEN.过早的卵巢功能不充分

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