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成熟卵细胞的发育潜力来自于在体外成熟的救援
Adi Kuperman Shani1, Lilach Marom Haham1, Hanna Balakier2
1CReATe Fertility Centre, Toronto, Ontario, Canada; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Fertility and sterility
|May 31, 2023
概括
救援体外成熟 (IVM) 可以从刺激周期中产生更成熟的卵细胞,改善低卵细胞产量患者怀孕的机会. 这种方法为移植提供了额外的可行的胚胎,最大限度地提高了生育治疗的成功率.
科学领域:
- 生殖医学 生殖医学
- 在体外受精过程中受精.
- 卵细胞成熟的过程
背景情况:
- 在试管婴儿中控制卵巢刺激的目的是最大限度地提高成熟卵细胞的检索.
- 在刺激周期中获取的不成熟卵细胞往往代表了潜在的生殖材料的损失.
- 救援体外成熟 (IVM) 提供了一个成熟这些不成熟卵细胞的策略.
研究的目的:
- 通过救援IVM成熟的不成熟卵细胞与在体内成熟的兄弟卵细胞的发育能力进行比较.
- 为了评估救援IVM对受精,切割,爆发和化率的影响.
- 为了评估从救援IVM卵细胞中获得的胚胎转移后的怀孕结果.
主要方法:
- 追溯队列研究涉及200个受控的卵巢刺激周期.
- 未成熟的卵子细胞 (胚芽囊泡和第I阶段) 被培养用于体外成熟.
- 卵子通过细胞内质精子注射进行了受精,并评估了结果胚胎的发育参数和 ploidy.
主要成果:
- 救援IVM成功成熟了大量未成熟卵细胞 (GV和MI阶段).
- 救援IVM卵细胞的受精率与体内成熟的兄弟卵细胞相当.
- 虽然切割和爆发率在救援IVM胚胎中较低,但胚胎囊化和"良好的质量"率相似,从21次转移中有3例活产.
结论:
- 救援IVM可以提供额外的成熟卵细胞和可活的胚胎细胞在同一刺激周期内进行转移.
- 这种方法对于卵细胞成熟率低或卵细胞产量低的患者尤其有益.
- 通过救援IVM最大限度地利用卵细胞可以在辅助生殖技术中提高怀孕和活产率.
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