维生素K2的神经保护作用对抗肠道失调症与相关的认知衰退
Kaberi Chatterjee1, Papiya Mitra Mazumder1, Suparna Roy Sarkar1
1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, India.
Physiology & behavior
|May 31, 2023
概括
维生素K2补充恢复了肠道细菌,并改善了小鼠的认知功能,这些小鼠经历了抗生素诱导的肠道失调. 这种维生素K2治疗也减少了肠道和大脑的炎症和氧化应激.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 营养科学 营养科学
背景情况:
- 肠道微生物组通过肠-大脑轴影响中枢神经系统,影响精神疾病.
- 维生素K2 (Menaquinones) 对于骨健康和预防冠状动脉化而闻名.
- 肠道功能障碍越来越多地与认知障碍有关.
研究的目的:
- 调查维生素K2 (MK-7) 在缓解与肠道失调相关的认知衰退中的作用.
- 分析维生素K2对肠道微生物群组成,炎症,氧化应激和神经元健康的影响.
主要方法:
- 在小鼠中使用安皮西林诱导了肠道功能障碍.
- 小鼠接受了维生素K2补充剂,有或没有抗生素.
- 分析了肠道微生物的基因表达.
- 行为研究评估了认知功能.
- 评估了肠道和大脑的抗炎,氧化和组织病理变化.
主要成果:
- 抗生素治疗减少了有益的细菌 (乳酸菌,双菌,菌,菌),维生素K2恢复了这些细菌.
- 用抗生素治疗的小鼠表现出认知障碍,但服用维生素K2可以扭转这种缺陷.
- 维生素K2防止了结肠和大脑中髓氧化酶的增加.
- 维生素K2降低了抗生素诱导的乙胆酶和氧化应激标志物.
- 维生素K2保护了海马神经元,并防止了抗生素引起的肠道超结构变化.
结论:
- 维生素K2的补充可以改善肠道失调症的背景下认知功能.
- 维生素K2减轻了抗生素诱导的肠道失调,炎症和氧化应激在肠道和大脑.
- 维生素K2可以保护海马神经元免受损伤,这表明它具有神经保护作用.
相关概念视频
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
166
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
166
01:18Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.3K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.3K
01:05Physiology of Enteric Nervous System and Gut Health
334
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
334
01:30Vitamins
827
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
827
01:29Drugs Affecting Neurotransmitter Synthesis
1.4K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.4K
01:25Role of Vitamins in Maintaining Bone Health
3.5K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.5K