30年来,基于遥测的数据采集用于评估心血管药物安全性:应用和优化
Elham Ataei Alizadeh1, Karin Graf1, Jessica Schiwon1
1Department of Drug Discovery Sciences, General Pharmacology Group, Boehringer Ingelheim Pharma GmbH & Co KG, Germany.
Journal of pharmacological and toxicological methods
|May 31, 2023
概括
这份综述涵盖了30年来对有意识动物进行药物安全性评估的改进,重点是心血管研究的远程测量. 我们强调了提高数据质量和动物福利的技术解决方案.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 研究中的动物福利.
- 心血管生理学心血管生理学
背景情况:
- 在使用有意识的动物对新药的安全性评估方面有30年的经验.
- 在临床前安全研究中应对技术挑战方面建立了专业知识.
- 专注于提高数据质量和动物福利.
研究的目的:
- 审查三十年来药物安全评估的技术挑战和解决方案.
- 为突出心血管研究基于遥测的数据采集方面的进展.
- 讨论不断发展的技术方面和CV研究遥测的新应用.
主要方法:
- 审查动物安全评估中的历史技术方法.
- 详细检查基于遥测的数据采集系统.
- 对心血管功能研究的特定应用的分析.
主要成果:
- 确定30年来实施的关键技术挑战和成功解决方案.
- 演示遥测在提高心血管评估数据质量的作用.
- 遥测技术的发展导致了新的研究应用.
结论:
- 持续的技术创新对于在有意识的动物中推进药物安全性评估至关重要.
- 基于遥测的数据采集显著提高了心血管研究质量和动物福利.
- 遥测的发展为临床前心血管研究提供了更多的可能性.
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