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Updated: Jul 28, 2025

Cell Type-specific Gene Expression Profiling in the Mouse Liver
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通过激活肝细胞重编程,IGF2BP3/HIF1A/YAP信号传导在驱动急性至慢性肝衰竭中发挥作用

Ke Cheng1, Shu Liu1, Cai Li1

  • 1Department of Transplantation, The Third Xiangya Hospital, Central South University, China; Engineering and Technology Research Center for Transplantation Medicine of National Health Commission, China.

Cellular signalling
|May 31, 2023
PubMed
概括

我们发现IGF2BP3/HIF1A/YAP信号驱动肝细胞重编程,导致急性至慢性肝衰竭 (ACLF) 的肝损伤. 这一发现为ACLF治疗提供了潜在的治疗点.

关键词:
急性至慢性肝功能衰竭 (ACLF)肝细胞重编程/胎儿肝脏计划低氧诱导因子 (HIF) 是指低氧诱导因子.类似胰岛素的生长因子-2RNA结合蛋白-3 (IGF2BP3)N6-甲基氨酸 (m6A) 是一种RNA修饰的RNA.是的相关蛋白 (YAP) 是的

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