在患有早期双相情感障碍的患者中,大脑网络内部和大脑网络之间存在异常的功能连接
Ziyi Hu1, Yongming Tan1, Fuqing Zhou1
1Department of Radiology, the First Affiliated Hospital of Nanchang university, Nanchang 330006, China.
Journal of affective disorders
|May 31, 2023
概括
早期出现的双相情绪障碍 (BD) 显示大脑网络连接的改变,影响执行控制,注意力和认知. 这些发现为BD提供了对BD的新见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 早期出现的双相情感障碍 (BD) 在理解其神经生物学基础方面提出了独特的挑战.
- 休息状态功能磁共振成像 (fMRI) 对于调查大脑网络变化至关重要.
研究的目的:
- 通过使用独立组件分析 (ICA) 在早期出现的双相情感障碍 (BD) 中的大脑网络中研究功能连接 (FC) 和功能网络连接 (FNC) 模式.
- 探索改变大脑网络连接和神经心理缺陷在早期发病的BD之间的关系.
主要方法:
- 使用独立组件分析 (ICA) 来从43名早期发病的BD患者和21名健康对照 (HC) 中提取静止状态大脑功能网络.
- 计算了网络内部的功能连接 (FC) 和网络之间的功能网络连接 (FNC).
- 评估了连接性变化和神经心理评分之间的相关性.
主要成果:
- 早期发病的BD患者在前置默认模式网络 (aDMN),后置默认模式网络 (pDMN) 和感觉运动网络 (SMN) 中表现出改变的FC.
- 在几个网络之间观察到FNC的增加,包括pDMN-视觉,lFPN-aDMN和DAN-VAN.
- 特定的FNC变化与焦虑,睡眠障碍,绝望和认知障碍正相关.
结论:
- 早发性BD的特点是神经功能网络的广泛变化,影响执行控制,注意力和感知调节.
- 这些发现为早期发病的BD病变发生提供了新的神经成像证据.
- 识别的网络变化可以作为治疗干预的潜在目标.
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