在帕金森病患者的行走,姿势和言语中协调硬
Dobromir Dotov1, Valérie Cochen de Cock2,3, Valérie Driss4
1Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Canada.
Journal of motor behavior
|May 31, 2023
概括
在帕金森病 (PD) 中的协调刚性 (CR) 在步态,姿态和言语方面进行了调查. 研究结果表明,CR表现为运动变异性减少,有助于疾病分类.
科学领域:
- 神经科学是一个神经科学.
- 生物物理学的生物物理.
- 运动科学 运动科学
背景情况:
- 帕金森病 (PD) 通常会损害协调,导致运动异常.
- 协调刚性 (CR),一个研究较少的模式,涉及硬的,非随机的运动.
- 了解CR对于描述PD相关的运动缺陷至关重要.
研究的目的:
- 调查中期帕金森病 (PD) 患者协调刚性 (CR) 的存在和特征.
- 在不同的运动任务中分析CR:步态,静静的姿态和言语.
- 评估CR相关动态对PD分类的潜力.
主要方法:
- 利用动态和语音记录来分析多关节和多肌肉协调动态.
- 反映系统动态的计算措施,包括自由度和非线性相互作用.
- 根据CR特征进行疾病分类的员工监督机器学习.
主要成果:
- 患有PD的患者在垂直步行轴上的动态分歧 (不稳定性减少) 减少.
- 在PD的姿势波动显示在前后轴上增加了规律性.
- 在PD中,语音动态表现出更高的可预测性,与CR一致.
- 与CR相关的特征实现了82%的准确度,81%的灵敏度和85%的特异性,用于对PD进行分类.
结论:
- 协调刚性 (CR) 是帕金森病中等阶段的可辨别特征,涉及步态,姿态和言语.
- CR表现为动态变化减少和运动控制可预测性增加.
- 由CR衍生的特征具有显著的临床意义,有效地帮助PD诊断和分类.
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