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野生类型和病原性形式的乌比奎林2对自-溶酶体通路的组件进行差异调节

Akiko Idera1, Lisa M Sharkey2, Yuki Kurauchi1

  • 1Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.

Journal of pharmacological sciences
|May 31, 2023
PubMed
概括

乌比基林2 (UBQLN2) 突变会影响伴侣介导的自 (CMA) 和宏观自 (MA). 与ALS相关的UBQLN2突变加剧了这些退化途径缺陷,可能导致X相关的肌性侧面硬化症 (ALS) 中的神经退行.

关键词:
肌缩性侧面硬化症 (AMLS) 是一种疾病.陪伴者介导的自细胞.宏观自的过程乌比奎林 2 2 乌比奎林

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