在婴儿的规范性心声图左心室参数和参考间隔
R Ottilia B Vøgg1, Anne-Sophie Sillesen2, Jan Wohlfahrt3
1Department of Cardiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Journal of the American College of Cardiology
|May 31, 2023
概括
这项研究建立了使用心声学对新生儿左心室 (LV) 测量的新参考间隔和z-score. 这些发现为儿科心脏病学家提供了必要的数据,以准确评估婴儿的心脏健康.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 新生儿心声学 新生儿心声学
- 心脏生理学 心脏生理学
背景情况:
- 准确的儿科心声回声学参考间隔对于区分正常变异与病理学至关重要.
- 左心室 (LV) 参数是新生儿临床结果的关键预测指标.
- 对健康新生儿的现有参考数据有限,导致正常范围的近似值不足.
研究的目的:
- 开发规范性参考间隔和z-score,用于对LV结构和功能的二维回声心脏学测量.
- 建立基于大量健康新生儿队列的可靠数据.
主要方法:
- 分析了13,454名健康新生儿的心声图 (哥本哈根婴儿心脏研究).
- 包括按期出生,出生后30天内出生,没有先天性心脏病的婴儿.
- 模拟10个LV参数与身体表面积,使用4个统计组件的联合建模.
主要成果:
- 开发了10个LV参数的规范性参考间隔和z分数.
- 在没有分层的情况下,基准间隔在性别方面表现良好.
- 对于7天以下的婴儿和7-30天的婴儿,需要单独的模型.
结论:
- 为新生儿10种广泛使用的LV心声学测量提供了规范性参考间隔和z-score.
- 提供了儿童心脏病学家临床应用的基本参考材料.
- 提高新生儿心脏评估的诊断准确度.
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