2'-糖乳糖缓解早期断奶引起的焦虑行为,杏仁核过活,以及肠道微生物群变化
Ryota Araki1, Yuki Tominaga1, Ryo Inoue2
1Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University.
Biological & pharmaceutical bulletin
|May 31, 2023
概括
早期的生活压力会导致焦虑和大脑变化. 补充2'-fucosyllactose (2'-FL),一种母乳寡糖类,减少了暴露于早期压力的小鼠的焦虑和正常化大脑活动.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 发展生物学 发展生物学
背景情况:
- 早期的生活压力显著影响中枢神经系统 (CNS) 的发展,并带来长期后果.
- 大脑-肠-微生物群轴促进中枢神经系统和肠道细菌之间的通信.
- 益生菌可能通过肠道微生物群影响中枢神经系统的发育.
研究的目的:
- 为了研究2-fucosyllactose (2-FL),一种人乳寡糖的作用,对小鼠早期生活压力引起的焦虑.
- 检查2 -FL对与早期压力相关的行为,神经组织学和便微生物群变化的影响.
主要方法:
- 在早期断奶 (17天) 和正常断奶 (24天) 的小鼠身上进行了行为测试 (升高加迷宫).
- 神经组织学分析使用c-Fos染色在杏仁体中确定了神经元活动.
- 便微生物组合被分析在食控制或2 -FL饮食的小鼠.
主要成果:
- 与对照组相比,早期断奶的小鼠表现出增加的焦虑类行为和更高的杏仁体c-Fos表达.
- 断奶后给2 -FL缓解了这些行为和神经异常.
- 早期断奶改变了便微生物群的组成,通过2-FL补充剂进行调节.
结论:
- 人类牛奶寡糖化物2-FL在缓解早期生活压力引起的焦虑和杏仁核过度活动方面表现出有效性.
- 2 -FL影响肠道微生物群的组成,这表明它在减轻与压力有关的神经发育变化方面发挥了作用.
- 这些发现突出了2-FL作为通过大脑-肠-微生物群轴对早期压力诱导疾病的干预措施的潜力.
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