在新诊断的2型糖尿病患者中,可溶性内林水平的增加与内皮功能障碍有关
Xiaobing Dou1, Xiujing Wang2, Xiuhua Yu3
1School of Life Science, Zhejiang Chinese Medical University, Zhejiang 310053, P. R. China.
Endocrine journal
|May 31, 2023
概括
新确诊的2型糖尿病 (T2DM) 患者表现出更高的可溶性内分泌素 (sEng) 水平和受损的内皮功能,以较低的反应性高血压指数 (RHI) 显示. 升高的sEng与T2DM中这种内皮功能障碍相关.
科学领域:
- 心血管研究研究心血管研究
- 内分泌学 在内分泌学.
- 糖尿病是一种糖尿病.
背景情况:
- 内皮功能障碍 (ED) 是2型糖尿病 (T2DM) 的宏血管并发症的关键因素.
- 溶性内分泌素 (sEng) 干扰转化生长因子β1 (TGF-β1) 介导的内皮保护.
- 反应性高血压周围动脉度计 (RH-PAT) 和其指数 (RHI) 是评估ED的新兴工具.
研究的目的:
- 为了研究新诊断的未经治疗的T2DM患者的血清sEng水平.
- 在这个队列中检查血清sEng水平和内皮功能 (RHI) 之间的相关性.
- 为了评估结构性血管变化,使用常见的动脉内心介质厚度 (CCA-IMT) 和脚-手腕指数 (ABI).
主要方法:
- 对34名新诊断T2DM患者和53名健康对照患者的临床数据的回顾性分析.
- 通过ELISA测量血清sEng水平.
- 使用RH-PAT计算RHI进行评估的内皮功能.
- 测量CCA-IMT和ABI以评估结构性血管变化.
主要成果:
- 与对照组相比,T2DM组的血清sEng水平显著升高 (p < 0.05).
- 在T2DM组中,RHI明显低于对照组 (p < 0.05).
- 在T2DM患者中,血清sEng水平与RHI有显著的负相关性 (r = 0.354,p = 0.041).
结论:
- 新诊断的T2DM患者表现出血清sEng水平升高和内皮功能受损.
- 血清sEng增加与RHI相反相关,这表明T2DM与内皮功能障碍有联系.
- 虽然sEng和RHI相关,但sEng,CCA-IMT和ABI在这个队列中与T2DM状态本身没有显著的相关性.
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