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从商业可用的产品中制备的阿里皮普拉的可口性:改善患者坚持治疗的药物配方
Sayuri Kawamoto1, Shimako Tanaka1, Motoyasu Miura1
1Department of Pharmacy Practice and Science, School of Pharmaceutical Sciences University of Shizuoka.
Chemical & pharmaceutical bulletin
|May 31, 2023
概括
阿里皮普拉 (ARP) 是为了改善精神疾病中药物坚持而开发的. 两种配方,可可味 (ABC-ARP-G) 和葡萄味 (GF-ARP-G),在健康志愿者中显示出高口感和可接受性.
科学领域:
- 制药科学 制药科学
- 精神病学是一个精神病学.
- 药物输送系统 药物输送系统
背景情况:
- 药物坚持对于有效治疗精神疾病至关重要.
- 工业制造的制药产品可能会对患者的坚持提出挑战.
- 量身定制的配方提供个性化的剂量形式,以满足个体患者的需求并改善遵守.
研究的目的:
- 开发和评估新型阿里皮普拉 (ARP) (ARP-Gs) 的口感,作为定制制制的制药配方.
- 在健康志愿者中评估ARP-Gs两种不同的感官掩盖策略的可接受性.
- 确定这些新型配方是否可以提高精神病治疗的药物坚持.
主要方法:
- 使用商业ARP配方制备阿里皮普拉 (ARP) (ARP-Gs).
- 使用可可和水果风味,包括阿斯巴甜,可可粉,香 (ABC-ARP-G) 和葡萄 (GF-ARP-G) 的ARP-Gs的体感掩饰.
- 每次试验涉及10名健康志愿者的口味感测试,通过100毫米视觉模拟尺度 (VAS) 评估口味性,使用5分评分尺度评估可接受性,并进行接收器操作特征 (ROC) 曲线分析.
主要成果:
- 结合阿斯巴甜,可可粉和香 (ABC-ARP-G) 的可可口味的ARP-Gs显示出最高的口感分数.
- 葡萄风味的ARP-Gs (GF-ARP-G) 也在水果风味的选项中获得了最高的口感分数.
- 无论是ABC-ARP-G还是GF-ARP-G的口感分数都明显超过了ROC曲线分析确定的可接受性切断值.
结论:
- 已经成功开发了两种具有有效感官掩饰的阿里皮普拉 (ARP-Gs) 类型 (ABC-ARP-G和GF-ARP-G).
- 这些量身定制的ARP-G配方显示出有希望的口感和可接受性,表明患者使用的潜力.
- ARP-Gs代表了一种可行的替代药物配方,可以改善药物服药性,并满足精神病治疗中的特定患者需求.
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