创新的评分系统将风险分层为从J-MACS注册数据中接受耐用左心室辅助设备的患者
Teruhiko Imamura1, Koichiro Kinugawa1, Takashi Nishimura2
1Second Department of Internal Medicine, University of Toyama.
概括
开发了一种新的J-MACS风险评分,用于预测日本患者的3年死亡率,这些患者接受了用于目的地治疗 (DT) 的耐用左心室辅助器件 (LVAD). 这一分数比现有模型提供了更好的可预测性.
科学领域:
- 心脏病学 心脏病学
- 医疗器械 医疗器械
- 公共卫生 公共卫生
背景情况:
- 使用耐用左心室辅助装置 (LVADs) 的目的地治疗 (DT) 现在已在日本批准用于无法接受心脏移植的患者.
- 在日本人群中最佳选择DT的候选人需要一个既定的风险评分.
研究的目的:
- 构建和验证一种新的风险评分,用于预测日本患者的3年死亡率,这些患者接受了针对DT的持久LVAD植入.
主要方法:
- 利用了日本机械辅助循环支持 (J-MACS) 注册表中的1287名患者的数据.
- 使用衍生队列 (494名患者) 开发了基于年龄,先前心脏手术,血清肌素和CVP/PAWP比率 (>0.71) 的风险评分.
- 在一个单独的队列 (487名患者) 中验证了得分的预测性能.
主要成果:
- 新建的J-MACS风险评分准确预测了三年死亡率.
- 在验证队列中,J-MACS风险得分与传统得分 (HeartMate II,HeartMate 3) 相比,具有更高的可预测性.
结论:
- 来自日本大型多中心数据的J-MACS风险评分有效估计持久LVAD植入后的3年死亡率.
- 需要进一步验证,以确认J-MACS评分对指导DT适用性的临床有用性.
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