人体免疫缺陷病毒和C型肝炎病毒的器官捐赠者:扩大捐赠者池
Jordan Salas1, Kaitlyn Storm2, Christine M Durand2
1Department of Medicine, Johns Hopkins University School of Medicine, 2000 East Monument Street, Baltimore, MD 21205, USA; Department of Medicine, Oregon Health & Science University School of Medicine, 3181 Southwest Sam Jackson Park Road, Portland, OR, USA.
Infectious disease clinics of North America
|May 31, 2023
概括
使用来自可治疗感染的捐赠者的器官,如艾滋病毒和C型肝炎病毒 (HCV),可以改善器官移植. 虽然HIV移植显示出希望,但障碍仍然存在;HCV移植提供了卓越的结果,并减少了所有接受者的等待时间.
科学领域:
- 移植免疫学 移植免疫学
- 移植中的传染病.
- 器官捐献者的使用率.
背景情况:
- 来自可治疗感染的捐赠者的器官可以提高移植质量和数量.
- 对HIV阳性捐赠者与HIV阳性接受者进行和肝移植的试点研究显示出出色的早期结果.
- 目前的障碍限制了每年进行的HIV阳性供体移植的数量.
研究的目的:
- 审查目前使用可治疗感染的捐赠者器官移植器官的现状和潜力.
- 要突出肝炎C病毒 (HCV) 感染的捐赠器官在未感染的接受者中的成功.
- 识别在扩大器官捐献池的挑战和机会.
主要方法:
- 对艾滋病毒和HCV供体器官移植的试点研究和临床结果的审查.
- 分析影响捐赠者和移植人数的因素.
- 对受感染捐献者的器官接受者的治疗策略的评估.
主要成果:
- 艾滋病毒捐赠者到接受者移植显示有前途的早期结果,但面临实施障碍.
- 由于有效的直接作用抗病毒疗法,HCV捐献器官越来越多地用于未感染HCV的接受者.
- 在各种器官类型中,HCV供体器官移植与良好的结果和减少等待时间有关.
结论:
- 扩大从可治疗感染的捐赠者获得器官的使用,特别是HCV,是增加器官可用性的可行策略.
- 克服艾滋病毒供体器官移植的障碍对于实现其全部潜力至关重要.
- 直接作用的抗病毒药物彻底改变了感染HCV的捐赠器官的使用,使得更广泛的接受者受益.
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