病理学家在细胞癌管理中的作用
Sayed Matar1, Nourhan El Ahmar1, Yasmin Nabil Laimon1
1Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Hematology/oncology clinics of North America
|May 31, 2023
概括
病理学家在通过识别分子变化和预测生物标志物来管理细胞癌 (RCC) 中发挥着至关重要的作用. 他们的不断发展的专业知识支持高级RCC患者用免疫检查点抑制剂治疗的精准医学策略.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 遗传学 是一个遗传学.
背景情况:
- 最近在了解细胞癌 (RCC) 中分子变化的进展.
- 引入免疫检查点抑制剂 (ICI) 用于高级RCC治疗.
- 病理学家在指导患者管理和治疗选择方面日益重要.
研究的目的:
- 检查病理学家在细胞癌 (RCC) 患者护理中的不断变化的作用.
- 突出病理学家在确定RCC的预测生物标志物的贡献.
- 讨论精准医学策略在RCC管理中的整合.
主要方法:
- 对RCC分子病理学当前文献的综述.
- 分析免疫检查点抑制剂对RCC治疗模式的影响.
- 在RCC中讨论诊断和预后生物标志物识别.
主要成果:
- 病理学家对于诊断RCC亚型和识别关键分子改变至关重要.
- 病理学家对生物标记物的鉴定对于选择合适的治疗方法至关重要,包括ICI.
- 病理学家的见解有助于开发针对RCC的个性化治疗方法.
结论:
- 病理学家在RCC管理中的作用已经远远超出了传统诊断的范围.
- 病理学家对于在先进的RCC中实施精准医学至关重要.
- 准确的病理评估对于优化ICI等新型疗法患者的治疗结果至关重要.
相关概念视频
Chronic Kidney Disease III: Interprofessional Care
51
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
51
Urinary Tract Calculi III: Medical Management
9
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
9
Acute Kidney Injury IV: Diagnostic Studies and Prevention
41
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
41
Kidney Transplant III: Nursing Management
41
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
41
Kidney Transplant II: Surgical Procedure
37
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
37
Chronic Kidney Disease I: Introduction
48
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
48


