激进切除术的5因素脆弱性指数:简化个性化手术前风险分层
Benjamin N Schmeusser1, Viraj A Master2
1Department of Urology, Emory University School of Medicine, Atlanta, GA.
Urologic oncology
|May 31, 2023
概括
5因素修改的脆弱性指数 (5-IFi) 有助于预测癌激进切除术后的并发症. 较高的分数表明风险增加,有助于老年患者的手术决定.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 老年人手术是一门老年人手术.
- 在瘤学瘤学.
背景情况:
- 彻底切除术是大型细胞癌的标准.
- 由于癌症发病率上升和人口老龄化,在手术前确定高风险患者至关重要.
- 五因素修改的脆弱性指数 (5-IFi) 评估了功能状态,糖尿病,COPD,CHF和高血压等并发症.
研究的目的:
- 评估5因子修改脆弱指数 (5-IFi) 在预测因细胞癌进行激进切除术的患者的术后结果中的有用性.
- 与其他脆弱指数相比,评估5-IFi的实用临床价值.
主要方法:
- 对接受激进切除术的患者的回顾性分析.
- 基于手术前并发症的5因素修改的脆弱指数 (5-IFi) 的计算.
- 5-IFi得分与术后发病率和死亡率的相关性.
主要成果:
- 较高的5-IFi得分与术后发病率和死亡率的风险增加有显著关联.
- 5-IFi表明,在接受激进切除术的患者中,存在显著的不良结果风险.
- 简化的5组分指数比以前的脆弱性测量方法更具临床实用性.
结论:
- 五因素修改的脆弱指数 (5-IFi) 是一个有价值的工具,用于在接受激进切除术的患者中进行风险分层.
- 使用5-IFi进行个性化风险评估可以为细胞癌患者,特别是老年人提供共享的临床和手术决策信息.
- 5-IFi提供了一种务实的方法来识别患有复杂术后病程风险的患者.
相关概念视频
Renal Failure: Dose Adjustments
127
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
127
Kidney Transplant II: Surgical Procedure
37
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
37
Factors Affecting Renal Clearance: Renal Impairment
125
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
125
Acute Kidney Injury I: Introduction
39
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
39
Kidney Transplant III: Nursing Management
41
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
41
Acute Kidney Injury IV: Diagnostic Studies and Prevention
41
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
41


